Molecular Insights into Muscle Homeostasis, Atrophy and Wasting

Bianca    Maria    Scicchitano; Gabriella        Dobrowolny; Gigliola       Sica; Antonio       Musaro

doi:10.2174/1389202919666180101153911

Abstract

Muscle homeostasis is guaranteed by a delicate balance between synthesis and degradation of cell proteins and its alteration leads to muscle wasting and diseases.

In this review, we describe the major anabolic pathways that are involved in muscle growth and homeostasis and the proteolytic systems that are over-activated in muscle pathologies. Modulation of these pathways comprises an attractive target for drug intervention.

Keywords: Muscle homeostasis, Muscle atrophy, Degradation of cell proteins, Muscle wasting, Anabolic pathways, Muscle pathologies.

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Current Genomics

Title:Molecular Insights into Muscle Homeostasis, Atrophy and Wasting

Volume: 19 Issue: 5

Author(s): Bianca Maria Scicchitano*, Gabriella Dobrowolny, Gigliola Sica and Antonio Musaro*

Affiliation:

Istituto di Istologia e Embriologia, Universita Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli, Largo Francesco Vito 1-00168, Roma,Italy

Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Rome,Italy

Keywords: Muscle homeostasis, Muscle atrophy, Degradation of cell proteins, Muscle wasting, Anabolic pathways, Muscle pathologies.

Abstract: Muscle homeostasis is guaranteed by a delicate balance between synthesis and degradation of cell proteins and its alteration leads to muscle wasting and diseases.

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Cite this article as:

Scicchitano Maria Bianca *, Dobrowolny Gabriella , Sica Gigliola and Musaro Antonio *, Molecular Insights into Muscle Homeostasis, Atrophy and Wasting, Current Genomics 2018; 19 (5) . https://dx.doi.org/10.2174/1389202919666180101153911

DOI https://dx.doi.org/10.2174/1389202919666180101153911	Print ISSN 1389-2029
Publisher Name Bentham Science Publisher	Online ISSN 1875-5488

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