Gold Catalysts in the Synthesis of Five-membered N-heterocycles

Title:Gold Catalysts in the Synthesis of Five-membered N-heterocycles

Volume: 4 Issue: 2

Author(s): Navjeet Kaur *

Affiliation:

• Department of Chemistry, Banasthali University, Banasthali-304022, Rajasthan,India

Keywords: Catalytic, catalysis, catalyzed synthesis, gold, heterocycles, nitrogen.

Abstract: Background: Due to significant biological activity associated with N-, O- and Sheterocycles, a number of reports for their synthesis have appeared in recent decades. Traditional approaches require expensive or highly specialized equipment or would be of limited use to the synthetic organic chemist due to their highly inconvenient approaches. This review summarizes the applications of gold catalysts with emphasis of their synthetic applications for nitrogen containing five-membered heterocylces.

Objective: The transition metal catalyzed protocols have attracted the attention as compared to other synthetic methodologies because they use easily available substrates to build multiply substituted complicated molecules directly under mild conditions. In organic synthesis one of the most powerful and useful protocols are constituted by transition metal catalyzed coupling transformations. The N-heterocycles are synthesized by this convenient and useful tool.

Conclusion: The efficient and chemoselective synthesis of heterocycles by this technique has appeared as an important tool. This review shows a highly dynamic research field and the employment of gold catalysts in organic synthesis. Several strategies have been pointed out in the past few years, to meet more sustainable, efficient and environmentally benign chemical products and procedures. The catalytic strategies have been focus of intense research because they avoid the use of toxic reagents. Among these catalytic strategies, highly rewarding and an important method in heterocycles synthesis is metal catalyzed synthesis.

Cite this article as:

Kaur Navjeet *, Gold Catalysts in the Synthesis of Five-membered N-heterocycles, Current Organocatalysis 2017; 4 (2) . https://dx.doi.org/10.2174/2213337204666171103142349