Microbial / Enzymatic Synthesis of Chiral Intermediates for Pharmaceuticals: Case Studies from BMS

Title: Microbial / Enzymatic Synthesis of Chiral Intermediates for Pharmaceuticals: Case Studies from BMS

Volume: 7 Issue: 13

Author(s): Ramesh N. Patel

Affiliation:

Keywords: melatonin, Alzheimer, enatioselective manner

Abstract: There has been an increasing awareness of the enormous potential of microorganisms and enzymes for the transformation of synthetic chemicals with high chemo-, regio- and enatioselective manner. Chiral intermediates are in high demand from pharmaceutical industries for the preparation bulk drug substances. In this review article, microbial / enzymatic processes mainly taken from the research carried out at BMS have been described for the synthesis of chiral intermediates for antihypertensive drugs, anticholesterol drugs, anticancer agents, antiviral agents, β3-receptor receptor agonists, melatonin receptor agonists, and anti-Alzheimers drugs.

Cite this article as:

Patel N. Ramesh, Microbial / Enzymatic Synthesis of Chiral Intermediates for Pharmaceuticals: Case Studies from BMS, Current Organic Chemistry 2003; 7 (13) . https://dx.doi.org/10.2174/1385272033486495