Abstract
This article (the third of three parts) reviews the use of 1,3-dipolar cycloaddition reactions of azides, diazo compounds, nitrile imines, azomethine imines and azomethine ylides in the construction of carbohydrate mimics. Preparation of triazole, tetrazole and other modified nucleosides, azasugars, polyhydroxylated alkaloids and carbocycles, pyrazolidine and pyrazoline systems is described. It is organized depending on the dipole employed and subdivided into separate sections according to the inter- or intramolecular fashion applied and the nature of dipolarophiles incorporated. It is mainly dedicated to the synthetic preparations and stereoselectivities observed with limited reports to biological tests and results.
Keywords: 1,3-Dipolar Cycloadditions, Carbohydrate Mimics, nitrile imines, azomethine, azasugars, pyrazolidine, stereoselectivities, polyhydroxylated
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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