摘要
背景:以前的研究发现老年BMI与认知功能的关系是相互矛盾的。本研究的目的是双重的;验证BMI和认知功能之间的关联,并检查这种关联是否受身高影响,当调整可能的协变量时。 方法:这项研究的数据由2287名60岁及以上的老年人组成,这些数据来自于2009年进行的一项名为“马来西亚老年人健康的决定因素:健康促进观点”的全国代表性人群调查。 结果:受访者平均年龄为68.7(SD = 6.6)岁。 MMSE测量的认知功能平均得分为24.5(SD = 5.6)。约有40%的受访者被列为超重。多重线性回归分析的结果显示BMI与认知功能之间显着相关(Beta = .10,p <.001)。在调整了可能的协变量之后,因子ANCOVA揭示了BMI和身高对认知功能之间的显着交互作用(F = 10.8,p <.001)。 结论:本研究结果显示BMI与认知功能正相关取决于身高,因此提示矮小人群可能成为预防痴呆的靶点。
关键词: 年龄,认知功能,BMI,老年人,流行病学,心理健康。
Current Alzheimer Research
Title:Body Mass Index (BMI) and Cognitive Functions in Later Life
Volume: 15 Issue: 2
关键词: 年龄,认知功能,BMI,老年人,流行病学,心理健康。
摘要: Background: The findings from previous studies exploring the association between BMI and cognitive function in the elderly are conflicting. The purpose of the present study is twofold; to verify the association between BMI and cognitive functions and examine whether this association is impacted by height, when adjusted for possible covariates.
Methods: The data for this study, consisted of 2287 older adults aged 60 years and above, drawn from a nationally representative population-based survey entitled “Determinants of Wellness among Older Malaysians: A Health Promotion Perspective” conducted in 2009.
Results: The mean age of the respondents was 68.7 (SD=6.6) years. The average score of cognitive function, measured by MMSE was 24.5 (SD=5.6). About 40% of the respondents were classified as overweight. Results of the multiple linear regression analysis revealed a significant association between BMI and cognitive function (Beta=.10, p<.001). The Factorial ANCOVA revealed significant interaction effect between BMI and height on cognitive function (F= 10.8, p<.001), after adjusting for possible covariates.
Conclusion: The findings from the current study indicating the positive association between BMI and cognitive function depends on height, therefore it is suggested that short people might be targeted for dementia prevention.
Export Options
About this article
Cite this article as:
Body Mass Index (BMI) and Cognitive Functions in Later Life, Current Alzheimer Research 2018; 15 (2) . https://dx.doi.org/10.2174/1567205014666171004114246
DOI https://dx.doi.org/10.2174/1567205014666171004114246 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Alterations in the Expression of Amyloid Precursor Protein Cleaving Enzymes mRNA in Alzheimer Peripheral Blood
Current Alzheimer Research Is VEGF a Key Target of Cotinine and Other Potential Therapies Against Alzheimer Disease?
Current Alzheimer Research Platelets in Atherothrombosis - Diagnostic and Prognostic Value of Platelet Activation in Patients with Atherosclerotic Diseases
Current Vascular Pharmacology Psychological Treatments for Cognitive Dysfunction in Major Depressive Disorder: Current Evidence and Perspectives<sup>§</sup>
CNS & Neurological Disorders - Drug Targets Neurological Disorders in Pregnancy
Current Women`s Health Reviews Antioxidant Therapy for Prevention of Inflammation, Ischemic Reperfusion Injuries and Allograft Rejection
Cardiovascular & Hematological Agents in Medicinal Chemistry Tau Pathology and Future Therapeutics
Current Alzheimer Research Mitochondrial Disturbances, Tryptophan Metabolites and Neurodegeneration: Medicinal Chemistry Aspects
Current Medicinal Chemistry Link Between Chronic Bacterial Inflammation and Alzheimer Disease
CNS & Neurological Disorders - Drug Targets Cholesterol Oxidation Products and Disease: An Emerging Topic of Interest in Medicinal Chemistry
Current Medicinal Chemistry Polypharmacology in a Single Drug: Multitarget Drugs
Current Medicinal Chemistry Anti-Amyloid Treatments in Alzheimers Disease
Recent Patents on CNS Drug Discovery (Discontinued) Serotonin 5-HT6 Receptor Antagonists for the Treatment of Alzheimers Disease
Current Topics in Medicinal Chemistry Recent Updates in the Alzheimer’s Disease Etiopathology and Possible Treatment Approaches: A Narrative Review of Current Clinical Trials
Current Molecular Pharmacology Mechanisms of Action of Metformin in Type 2 Diabetes and Associated Complications: An Overview
Mini-Reviews in Medicinal Chemistry TNF-α Inhibitors with Anti-Oxidative Stress Activity from Natural Products
Current Topics in Medicinal Chemistry Colchicine: An Ancient Drug with Multiple Benefits
Current Pharmaceutical Design Cerebrovascular Amyloidosis and Dementia
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Domperidone in Parkinson’s Disease: A Perilous Arrhythmogenic or the Gold Standard?
Current Drug Safety On the Involvement of H2S in Nitroso Signaling and Other Mechanisms of H2S Action
Current Pharmaceutical Biotechnology