摘要
淀粉样蛋白是一类由形成淀粉样纤维的蛋白质的细胞外沉积引起的疾病。淀粉样变性是根据构成淀粉样纤维的主要蛋白质或肽来分类的。淀粉样变的最有效诊断方法是质谱法。质谱法能够以极高的灵敏度和特异性确认生物样品中淀粉样蛋白原纤维的蛋白前体，这对淀粉样蛋白的正确分型至关重要。由于生物样品非常复杂，质谱法通常与液相色谱或毛细管电泳等技术相结合，从而能够在质谱分析前分离蛋白质。因此，质谱法是所谓的“连字符技术”的重要组成部分，它优先结合不同的分析方法，以提供有关所研究问题的综合信息。在发现不同类型淀粉样变性的生物标志物时，断字方法非常有用。在淀粉样变的系统性形式中，聚集蛋白的分析通常是基于在受累器官或皮下脂肪T期的活检中获得的T期专刊。在某些情况下，当由于淀粉样纤维形成于脑等器官（阿尔茨海默病）而无法进行诊断活检时，可以进行体液中生物标志物的研究。目前，大规模的研究是为了寻找和验证更有效的生物标记物，这些标记物可以用于诊断程序。我们希望通过对T期、血液和脑脊液中蛋白质的分析，提出与质谱联用的诊断淀粉样变的方法。
关键词: amyloidosis神经退行性变的诊断，生物标志物，蛋白质组学，串联质谱法。
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