A Green Ultrasound Synthesis, Characterization and their Antibacterial Evaluation of Novel Transition Metal Complex of 2-amino-5-Aryl-1, 3, 4- THIADIAZOLE

Title:A Green Ultrasound Synthesis, Characterization and their Antibacterial Evaluation of Novel Transition Metal Complex of 2-amino-5-Aryl-1, 3, 4- THIADIAZOLE

Volume: 15 Issue: 7

Author(s): Satinder Kanwar, Dinesh K. Mehta*, Rina Das and Girish K. Gupta

Affiliation:

• Department of Pharmaceutical Chemistry, M.M. College of Pharmacy, Maharishi Markandeshwar University, Mullana, Ambala, Haryana- 133207,India

Keywords: Antibacterial activity, green chemistry, 1, 3, 4-thiadiazole, sonochemistry, regional, metal salt.

Abstract: In the present study a series of metal complex of [bis (2-amino-5-aryl-1,3,4-thiadiazole]2Cl (S1-S9) was synthesized by using ultrasound irradiation technique. The metal complex was synthesized by the reaction between ligand and appropriate metal salts (CuCl2. 2H2O, CoCl2. 6H2O, ZnCl2, MgCl2. 4H2O, NiCl2. 6H2O). The products were obtained in high yield and the reaction time was found to be shorter. The synthesized metal complexes were characterized by using UV-visible spectroscopy, FTIR, 1H NMR and Mass spectroscopy. The synthesized compounds were investigated for antibacterial potential against gram positive bacteria (Bacillus subtilis, Staphylococcus aureus) and gram negative bacteria (Pseudomonas aeruginosa, Escherichia coli). Significant activity was observed for synthesized metal complexes S6 and S7 against B. subtilis and S. aureus.

Cite this article as:

Kanwar Satinder , Mehta K. Dinesh *, Das Rina and Gupta K. Girish , A Green Ultrasound Synthesis, Characterization and their Antibacterial Evaluation of Novel Transition Metal Complex of 2-amino-5-Aryl-1, 3, 4- THIADIAZOLE, Letters in Organic Chemistry 2018; 15 (7) . https://dx.doi.org/10.2174/1570178614666170927162125