Abstract
Clusterin is a multifunctional glycoprotein whose role in cells has generated a great controversy in recent years. Since its discovery, numerous studies have linked clusterin expression deregulation with various physio-pathological processes such as cancer or Alzheimer's disease. Although the results of such investigations have sometimes been contradictory, mainly due to the dichotomous role of clusterin isoforms, it has been demonstrated that this protein is involved in diverse cellular processes, including apoptosis, cell cycle regulation, DNA repair or the acquisition of cell resistance against multiple conventional therapies.
These results, together with the breakthrough of gene therapies, have motivated a great effort to elucidate the importance of clusterin as a potential therapeutic target. However, the understanding of a single gene, with multiple RNA transcripts and several protein isoforms has turned out to be a complex task.
In this review, we summarize the studies published to date on factors that can affect clusterin expression and evaluate if a better understanding of this complex gene/protein would be useful to develop new treatment strategies for cancer and other pathologies.
Keywords: Clusterin, regulation, epigenetic, transcription factor, gene, cancer, Alzheimer's disease.
Graphical Abstract
Current Protein & Peptide Science
Title:Regulation of Clusterin Gene Expression
Volume: 19 Issue: 6
Author(s): Marilina Garcia-Aranda, Alfonso Serrano and Maximino Redondo*
Affiliation:
- Department of Biochemistry, REDISSEC, Hospital Costa del Sol, Carretera de Cadiz km, 187, 29600 Marbella. Malaga,Spain
Keywords: Clusterin, regulation, epigenetic, transcription factor, gene, cancer, Alzheimer's disease.
Abstract: Clusterin is a multifunctional glycoprotein whose role in cells has generated a great controversy in recent years. Since its discovery, numerous studies have linked clusterin expression deregulation with various physio-pathological processes such as cancer or Alzheimer's disease. Although the results of such investigations have sometimes been contradictory, mainly due to the dichotomous role of clusterin isoforms, it has been demonstrated that this protein is involved in diverse cellular processes, including apoptosis, cell cycle regulation, DNA repair or the acquisition of cell resistance against multiple conventional therapies.
These results, together with the breakthrough of gene therapies, have motivated a great effort to elucidate the importance of clusterin as a potential therapeutic target. However, the understanding of a single gene, with multiple RNA transcripts and several protein isoforms has turned out to be a complex task.
In this review, we summarize the studies published to date on factors that can affect clusterin expression and evaluate if a better understanding of this complex gene/protein would be useful to develop new treatment strategies for cancer and other pathologies.
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Cite this article as:
Garcia-Aranda Marilina , Serrano Alfonso and Redondo Maximino *, Regulation of Clusterin Gene Expression, Current Protein & Peptide Science 2018; 19 (6) . https://dx.doi.org/10.2174/1389203718666170918155247
DOI https://dx.doi.org/10.2174/1389203718666170918155247 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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