Nitric Oxide Regulation of Permeability in Human Cervical and Vaginal Epithelial Cells and in Human Endothelial Cells

Title: Nitric Oxide Regulation of Permeability in Human Cervical and Vaginal Epithelial Cells and in Human Endothelial Cells

Volume: 9 Issue: 5

Author(s): George I. Gorodeski

Affiliation:

Keywords: nitric oxide, no, nos, no synthase, nos isoforms, no regulation, no modulation

Abstract: This paper reviews new models of nitric-oxide (NO) - related regulation of transepithelial and transendothelial permeability in normal tissues, with emphasis on physiological relevance of the data. Novel data obtained in cultured human epithelial and endothelial cells indicate that NO can originate from different intracellular sources, and can be selectively regulated and employed to activate various intracellular mechanisms that will affect the permeability via different mechanisms. These models may be important for understanding NO regulation of permeability in vivo.

Cite this article as:

Gorodeski I. George, Nitric Oxide Regulation of Permeability in Human Cervical and Vaginal Epithelial Cells and in Human Endothelial Cells, Current Pharmaceutical Design 2003; 9 (5) . https://dx.doi.org/10.2174/1381612033391801