Abstract
Background: Ammonium bifluoride is a reagent widely used in organic synthesis; however, the systematic collection and classification have not been covered until now.
Methodology: In this review, we aim to systematically summarize the application of ammonium bifluoride in organic synthesis.
Conclusion: It can be used for deprotection of hydroxyl protected groups (esp. Silyl protection). It is also used for introducing F & N atoms into organic molecules; promoting cyclization reactions acting as a multifunctional reagent.
Keywords: Ammonium bifluoride, removal of hydroxyl protecting groups, fluoride source, nitrogen source, cyclization, multifunction reagent, organic synthesis.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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