Targeting CXCL12/CXCR4 Axis in Tumor Immunotherapy

doi:10.2174/0929867324666170830111531
摘要

具有趋化能力的趋化因子由具有8-10千道尔顿的小细胞因子家族组成。趋化因子通过运输和调节细胞增殖，迁移，活化，分化和归巢在免疫细胞中起作用。 CXCR-4是特异于基质衍生因子-1（SDF-1，也称为CXCL12）的α-趋化因子受体，已发现其在超过23种不同类型的癌症中表达。最近，SDF-1 / CXCR-4信号通路已成为人类肿瘤的潜在治疗靶点，因为它通过激活多种信号通路在肿瘤的发生和发展中发挥关键作用，如ERK1 / 2，ras，p38 MAPK，PLC / MAPK和SAPK / JNK，以及调节癌症干细胞。已经产生了CXCL12 / CXCR4拮抗剂，其已显示出令人鼓舞的抗癌活性结果。在这里，我们简要概述了CXCL12 / CXCR4轴作为癌症治疗的分子靶点。我们还根据最新文献和正在进行的研究进展，回顾了靶向CXCL12 / CXCR4轴与免疫疗法和/或化学疗法相结合的潜在效用。
关键词: 癌症，癌症干细胞，免疫疗法，CXCR4，CXCL12，趋化因子，千道尔顿。
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DOI https://dx.doi.org/10.2174/0929867324666170830111531	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X
当代药物化学

靶向肿瘤免疫治疗中的CXCL12 / CXCR4轴

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当代药物化学

靶向肿瘤免疫治疗中的CXCL12 / CXCR4轴

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