Diabetes Mellitus and Male Aging: Pharmacotherapeutics and Clinical Implications

Title:Diabetes Mellitus and Male Aging: Pharmacotherapeutics and Clinical Implications

Volume: 23 Issue: 30

Author(s): Swathi Putta, Ilaria Peluso, Nagendra Sastry Yarla, Eswar Kumar Kilari, Anupam Bishayee, Da-Yong Lu, George E. Barreto, Ghulam Md Ashraf, Luciana Scotti, Marcus T. Scotti, Rajeev K. Singla, Thonos Alexiou, Atanas G. Atanasov, Vadim V. Tarasov, P. Veera Bramhachari, Sarat Babu Imandi, Madhuri Chintala, Bechan Sharma, Marcella Reale, Rosanna Filosa, Gjumrakch Aliev and Mohammad Amjad Kamal*

Affiliation:

• King Fahd Medical Research Center, King Abdulaziz University, P. O. Box 80216, Jeddah 21589,Saudi Arabia

Keywords: Testosterone, andropause, hypogonadism, insulin, diabetes mellitus, proinflammatory cytokines.

Abstract: Andropause or male menopause is defined as androgen decline and onset of hypogonadism in the aging male. Testosterone deficiency in adult male is associated with diabetes mellitus, coronary artery disease, and heart failure. Type 2 diabetic male patients aged above 30 years showed low testosterone levels which is common in diabetic men and had symptoms of hypogonadism. Male sexual dysfunction among diabetic patients can include disorders of libido, ejaculatory problems, and erectile dysfunctions are common among people with diabetes, particularly in older men who had diabetes for years. Older diabetics tend to have both impaired insulin release as well as insulin resistance. There is growing evidence indicating the pathophysiological connections among the mechanisms of oxidative damage by disruption of the oxidative balance, increased levels of enzymatic glycation products in testicular region and glucose transporters, obesity and proinflammatory cytokines in male infertile patients with diabetes. Epidemiological studies suggest that many clinical findings in diabetics are linked to low testosterone levels. This article reviews pathophysiological mechanisms, observational studies, and clinical implications of testosterone therapy in type 2 diabetes mellitus.

Cite this article as:

Putta Swathi, Peluso Ilaria , Yarla Sastry Nagendra, Kilari Kumar Eswar , Bishayee Anupam, Lu Da-Yong, Barreto E. George , Ashraf Md Ghulam, Scotti Luciana, Scotti T. Marcus, Singla K. Rajeev, Alexiou Thonos, Atanasov G. Atanas, Tarasov V. Vadim, Bramhachari Veera P., Imandi Babu Sarat, Chintala Madhuri , Sharma Bechan , Reale Marcella , Filosa Rosanna, Aliev Gjumrakch and Kamal Amjad Mohammad *, Diabetes Mellitus and Male Aging: Pharmacotherapeutics and Clinical Implications, Current Pharmaceutical Design 2017; 23 (30) . https://dx.doi.org/10.2174/1381612823666170823103830