Abstract
Background: Microwave irradiation has emerged as a useful synthetic strategy for chemists and drug developers due to enhanced yields, regioselectivity, and faster reaction times. One area of importance in its practice has been the design of spiro compounds, which possess great interest on account of their natural occurrence and medicinal capabilities. The increasingly large number of these scaffolds and unlimited amount of methodologies utilized in their preparation have made them good candidates for the microwave assisted approach.
Conclusion: Therefore, this review emphasizes the use of microwave irradiation in the synthesis of spiro heterocyclic compounds.
Keywords: Spiro compounds, heterocycles, microwave, green synthesis.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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