Antimicrobial Activity and Molecular Docking of Tannins from Pimenta dioica

Title:Antimicrobial Activity and Molecular Docking of Tannins from Pimenta dioica

Volume: 15 Issue: 5

Author(s): Reham Al-Harbi, Mona Shaaban*, Razan Al-wegaisi, Fatma Moharram, Ola Abd El-Rahman and Shahenda El-Messery

Affiliation:

• Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Taibah University, Al Madinah Al Munawarah,Saudi Arabia

Keywords: Antimicrobial activity, pedunculagin, nilocitin, molecular docking, Pimenta dioica, tannins.

Abstract: Background: High rate of bacterial infection potentiates scientists to search natural products for new antimicrobial agents.

Methods: This research determines the antimicrobial activity of tannins isolated from Pimenta dioica leaves on Gram-positive and Gram-negative infectious organisms using agar diffusion method.

Results: All tested compounds were effective against Staphylococcus epidermidis, particularly pedunculagin and nilocitin exhibited broad spectrum antibacterial effects against tested isolates as quantified by microtiter plate dilution method.

Conclusion: This will open the era for in-vivo assessment of such compounds for clinical applications.

Cite this article as:

Al-Harbi Reham , Shaaban Mona*, Al-wegaisi Razan , Moharram Fatma , El-Rahman Abd Ola and El-Messery Shahenda , Antimicrobial Activity and Molecular Docking of Tannins from Pimenta dioica, Letters in Drug Design & Discovery 2018; 15 (5) . https://dx.doi.org/10.2174/1570180814666170810113850

DOI https://dx.doi.org/10.2174/1570180814666170810113850	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X