The Enzymatic Degradation of Heparan Sulfate

Title:The Enzymatic Degradation of Heparan Sulfate

Volume: 24 Issue: 8

Author(s): Laura S. Griffin and Tracey M. Gloster*

Affiliation:

• Biomedical Sciences Research Complex, North Haugh, University of St. Andrews, St. Andrews, KY16 9ST,United Kingdom

Keywords: Glycosaminoglycan, heparan sulfate, degradation, lysosome, mucopolysaccharidoses, enzymes.

Abstract: Glycosaminoglycans (GAGs) such as heparan sulfate (HS) interact with a number of factors in the extracellular matrix (ECM) and as a consequence play a key role in the metabolic processes occurring within the cell. The dynamic synthesis and degradation of HS (and all GAGs) are necessary for ensuring that optimal chains are present for these functions. The degradation of HS begins at the cell surface and finishes in the lysosome, after which components can be recycled. Deficiencies or mutations in the lysosomal enzymes that process GAGs result in rare Mucopolysaccharidoses disorders (MPSs). There are few treatments available for these genetically inherited diseases and those that are available often do not treat the neurological symptoms of the disease. In this review, we discuss the enzymes involved in the degradation of HS and their related diseases, with emphasis on those located in the lysosome.

Cite this article as:

Griffin S. Laura and Gloster M. Tracey *, The Enzymatic Degradation of Heparan Sulfate, Protein & Peptide Letters 2017; 24 (8) . https://dx.doi.org/10.2174/0929866524666170724113452

DOI https://dx.doi.org/10.2174/0929866524666170724113452	Print ISSN 0929-8665
Publisher Name Bentham Science Publisher	Online ISSN 1875-5305