Supramolecular Self-Assembled Nanogels a New Platform for Anticancer Drug Delivery

Title:Supramolecular Self-Assembled Nanogels a New Platform for Anticancer Drug Delivery

Volume: 23 Issue: 35

Author(s): Jaleh Varshosaz*, Somayeh Taymouri and Erfaneh Ghassami

Affiliation:

• Department of Pharmaceutics, School of Pharmacy and Novel Drug Delivery Systems Research Centre, Isfahan University of Medical Sciences, Isfahan,Iran

Keywords: Self assembly, nanogel, polymeric micelles, cancer chemotherapy, drug delivery, anticancer drugs.

Abstract: Polymer micellar nanogels are a group of core-shell polymeric micelles with swelling properties in aqueous media. Nanogel systems have proven their potential in controlled, sustained and targetable drug delivery area with no immunological responses. This review includes a comprehensive wide range of self-assembly of polymeric nanogels as delivery systems for anticancer drugs.

Nanogels are nanoparticulate drug delivery systems which are specially designed for enhanced target oriented and cellular uptake of drugs with emphasis on chemotherapeutic agents studied in this review. Self-assembling nanogels are based on natural substances or synthetic polymers including: hyaluronic acid, heparin, alginate, cyclodextrins, chondroeitin sulfate, starch, mannan, chitosan, pullulan, poly(N-isopropylacrylamide), polyvynil alcohol, Pluronic F127, polyacrylic acid, poly(hydroxylethyl methacrylate), poly[2- (dimethylamino)ethyl methacrylate and polylactide-co-glycolide-polyethylen glycol amphiphilic di or tri block copolymer used to deliver anticancer drugs are introduced and discussed.

Cite this article as:

Varshosaz Jaleh *, Taymouri Somayeh and Ghassami Erfaneh , Supramolecular Self-Assembled Nanogels a New Platform for Anticancer Drug Delivery, Current Pharmaceutical Design 2017; 23 (35) . https://dx.doi.org/10.2174/1381612823666170710121900