Abstract
This article (the second of three parts) reviews the use of 1,3-dipolar cycloaddition reactions of nitrones and the closely related oximes in the construction of carbohydrate mimics. Preparation of isoxazoline and carbocyclic nucleosides, isoxazoline fused systems, polyhydroxylated and aminopolyhydroxylated carbocycles and azasugars, amino sugars, polyhydroxylated alkaloids of the pyrrolidine and indolizidine series is described. It is organized depending on the dipole employed and subdivided into separate sections according to the inter- or intramolecular fashion applied and the nature of dipolarophiles and dipoles incorporated. It is mainly dedicated to the synthetic preparations and stereoselectivities observed with limited reports to biological tests and results.
Keywords: 1,3-Dipolar, Cycloadditions, Carbohydrate, Nitrones and Oximes, isoxazoline, polyhydroxylated alkaloids, stereoselectivities, dipolarophiles
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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