Acquired Hemophilia as Initial Presentation in a Patient with Systemic Lupus Erythematosus

Title:Acquired Hemophilia as Initial Presentation in a Patient with Systemic Lupus Erythematosus

Volume: 13 Issue: 3

Author(s): Zohre Khodamoradi, Mohammad Ali Nazarinia*Somaye Bazdar

Affiliation:

• Shiraz Geriatric Research Center, Shiraz University of Medical Sciences, Shiraz,Iran

Keywords: Hemophilia, systemic lupus erythematosus, factor VIII, hematoma, autoimmune diseases, hematuria.

Abstract: Background: Acquired hemophilia is a rare bleeding disease which might be associated with some autoimmune diseases. Acquired hemophilia may be the result of autoantibodies against factor VIII.

Case Presentation: In this study, we describe a 55 year old patient who developed hematoma and hematuria due to acquired hemophilia secondary to systemic lupus erythematosus (SLE). Then, she developed arthritis and thrombosis after some evaluations. Laboratory data showed prolonged aPTT, normal PT and platelet, low FVIII, high FVIII inhibitor, ANA, anti-ds-DNA, and anticardiolipin. This patient was treated with corticosteroids, FEIBA and rituximab, so she recovered and was discharged about seven days later.

Conclusion: We should consider lupus erythematosus in patients with acquired hemophilia. Some cases of acquired hemophilia may be an SLE manifestation, so we should consider this situation to diagnose the disease properly.

Cite this article as:

Khodamoradi Zohre, Nazarinia Ali Mohammad *, Bazdar Somaye , Acquired Hemophilia as Initial Presentation in a Patient with Systemic Lupus Erythematosus, Current Rheumatology Reviews 2017; 13 (3) . https://dx.doi.org/10.2174/1573397113666170519121952

DOI https://dx.doi.org/10.2174/1573397113666170519121952	Print ISSN 1573-3971
Publisher Name Bentham Science Publisher	Online ISSN 1875-6360