Leishmanicidal and Trypanocidal Activity of Metal Complexes with 1,2,4-Triazolo[1,5-a]pyrimidines: Insights on their Therapeutic Potential against Leishmaniasis and Chagas Disease

Title:Leishmanicidal and Trypanocidal Activity of Metal Complexes with 1,2,4-Triazolo[1,5-a]pyrimidines: Insights on their Therapeutic Potential against Leishmaniasis and Chagas Disease

Volume: 24 Issue: 25

Author(s): Juan M. Salas , Ana B. Caballero *, Ginés M. Esteban-Parra and José M. Méndez-Arriaga

Affiliation:

• Department of Inorganic and Organic Chemistry (Inorganic Chemistry Section), University of Barcelona, Martí i Franquès 1–11, 08028 Barcelona,Spain

Keywords: Triazolopyrimidine, metal complexes, Leishmania, Trypanosoma cruzi, leishmaniasis, Chagas disease, neglected tropical diseases.

Abstract: Since their first synthesis back in the early 20th century, 1,2,4-triazolo[1,5- a]pyrimidines have aroused increasing interest in very diverse areas ranging from chemotherapy to agriculture or even photography. Their similarity to purines confers a potential bioactivity and this feature has been wisely exploited for therapeutic use, including antifungal, antipyretic, analgesic, antiinflammatory, antitumoral and antiparasitic properties. In this review, we focus on the compounds that these nitrogen heterocycles form with metal ions and their antiparasitic activity and therapeutic potential against two neglected diseases of tropical prevalence, leishmaniasis and Chagas disease.

Cite this article as:

Salas M. Juan , B. Caballero Ana*, Esteban-Parra M. Ginés and Méndez-Arriaga M. José, Leishmanicidal and Trypanocidal Activity of Metal Complexes with 1,2,4-Triazolo[1,5-a]pyrimidines: Insights on their Therapeutic Potential against Leishmaniasis and Chagas Disease, Current Medicinal Chemistry 2017; 24 (25) . https://dx.doi.org/10.2174/0929867324666170516122024