摘要
背景:开发各种胶体纳米粒子(NPs)作为诊断性探针的努力在生物医学领域一直很有希望。 具体而言,胶体金纳米粒子(GNP)由于其独特的物理化学性质和极好的生物相容性而被广泛用作分子成像和药物递送的诊断性探针。 目的:本综述概述并讨论了控制几何形状(球形,棒状和笼状)的金纳米粒子合成方法,表面官能化(共价和非共价)以及相关的体外/体内细胞毒性以及一些 有趣的诊断(成像)和治疗(光热,药物输送)应用。 结果和结论:与其他传统的治疗药物相比,GNP具有几个优势,我们坚信基于GNP的临床方法将随着创新数量的不断增加而持续受到关注。
关键词: Theranostic探针,诊断和治疗,药物输送,等离子体激元,金纳米粒子。
图形摘要
Current Drug Targets
Title:Application of Plasmonic Gold Nanoparticle for Drug Delivery System
Volume: 19 Issue: 3
关键词: Theranostic探针,诊断和治疗,药物输送,等离子体激元,金纳米粒子。
摘要: Background: Efforts in developing various colloidal nanoparticles (NPs) as theranostic probes have been promising in the biomedical field. Specifically, colloidal gold nanoparticles (GNP) have been extensively utilized as a theranostic probe for molecular imaging and drug delivery owing to their unique physiochemical properties with excellent biocompatibility.
Objective: This review outlines and discusses the progress regarding gold nanoparticle synthesis methods for controlled geometry (spherical, rod, and cage), surface functionalization (covalent and non-covalent), and associated in vitro/in vivo cytotoxicity as well as some of the interesting diagnostic (imaging) and therapeutic (photo-thermal, drug delivery) applications.
Results and Conclusion: GNP possesses several advantages compared to other traditional theranostic agents, we firmly believe that GNP based clinical approach will gain continuous interest with increasing numbers of innovations.
Export Options
About this article
Cite this article as:
Application of Plasmonic Gold Nanoparticle for Drug Delivery System, Current Drug Targets 2018; 19 (3) . https://dx.doi.org/10.2174/1389450118666170427150257
DOI https://dx.doi.org/10.2174/1389450118666170427150257 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Related Journals
Related Books
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Exploiting Apoptosis Pathways for the Treatment of Pancreatic Cancer
Current Signal Transduction Therapy Chronographic Theory of Development, Aging, and Origin of Cancer: Role of Chronomeres and Printomeres
Current Aging Science Drug-Mediated Targeted Disruption of Multiple Protein Activities Through Functional Inhibition of the Hsp90 Chaperone Complex
Current Medicinal Chemistry Combined 3D-QSAR, Pharmacophore and Docking Studies on Benzenesulfonamide Derivatives as Potent 12-Lipoxygenase Inhibitors
Letters in Drug Design & Discovery Dynamic Simulations of Pathways Downstream of ERBB-Family, Including Mutations and Treatments: Concordance with Experimental Results
Current Cancer Drug Targets Design, Synthesis and in vitro Cytotoxicity Evaluation of New 3',4'-bis (3,4,5-trisubstituted)-4'H-spiro[indene-2,5'-isoxazol]-1(3H)-one Derivatives as Promising Anticancer Agents
Letters in Drug Design & Discovery Bladder Cancer: A Simple Model Becomes Complex
Current Genomics α7 Nicotinic Acetylcholine Receptors: A Therapeutic Target in the Structure Era
Current Drug Targets Smac-Derived Aza-Peptide As an Aminopeptidase-Resistant XIAP BIR3 Antagonist
Protein & Peptide Letters Oral Chemotherapy in Elderly Women with Metastatic Breast Cancer
Anti-Cancer Agents in Medicinal Chemistry α(N)-Heterocyclic Thiosemicarbazones: Iron Chelators that are Promising for Revival of Gallium in Cancer Chemotherapy
Anti-Cancer Agents in Medicinal Chemistry Synthesis and Structure Activity Relationship Study of N-substituted 3,5-diarylidenepiperidin- 4-ones as Potential Antitumor Agents
Anti-Cancer Agents in Medicinal Chemistry Molecular Targeting of Lymphatics for Therapy
Current Pharmaceutical Design Magnetic Resonance Elastography
Current Medical Imaging New Therapeutic Approaches to Liver Fibrosis: A Practicable Route?
Current Medicinal Chemistry Meet Our Editorial Board Member
Anti-Cancer Agents in Medicinal Chemistry Regulation of Multidrug Resistance by Pro-Inflammatory Cytokines
Current Cancer Drug Targets Editorial (Thematic Issue: The Biological Approach to Advanced Cancer: Are We in the Middle of the Road?)
Current Drug Targets Fastidious Anatomization of Biota Procured Compounds on Cancer Drug Discovery
Current Pharmaceutical Biotechnology Progress and Obstacles in the Application of Precision Medicine in the Management of Hepatocellular Carcinoma
Clinical Cancer Drugs