Food Protein Induced Proctocolitis: A Benign Condition with an Obscure Immunologic Mechanism

Title:Food Protein Induced Proctocolitis: A Benign Condition with an Obscure Immunologic Mechanism

Volume: 17 Issue: 1

Author(s): Sophia Tsabouri*, Nicolaos Nicolaou, Konstantinos Douros, Athina Papadopoulou and Kostas N. Priftis

Affiliation:

• Department of Paediatrics, Child Health Department, University of Ioannina School of Medicine, Ioannina, Greece. Stavrou Niarxou Av, Ioannina, 45500,Greece

Keywords: Breast feeding, food allergy, infants, immunologic response, intolerance, allergic proctocolitis.

Abstract: Food protein-induced proctocolitis (FPIP) is the most common colonic manifestation of food allergy in infants, accounting for up to 60% of exclusively breast-fed children. The causative foods derived from the mother’s diet, which are then excreted in her milk. The suggested risk factors for the development of FPIP are an immature immune system, altered intestinal permeability and other factors that activate local immune function, such as genetic susceptibility in combination with particularly sensitizing foods. FPIP is an enhanced immune responsiveness of some infants to very small amounts of food antigens, inducing an inflammatory mucosal response, mediated by T cells.

Cite this article as:

Tsabouri Sophia *, Nicolaou Nicolaos, Douros Konstantinos, Papadopoulou Athina and Priftis N. Kostas, Food Protein Induced Proctocolitis: A Benign Condition with an Obscure Immunologic Mechanism, Endocrine, Metabolic & Immune Disorders - Drug Targets 2017; 17 (1) . https://dx.doi.org/10.2174/1871530316666170331165356