羟基吡啶酮衍生物：一类具有治疗应用的迷人螯合剂 - 更新

Title:Hydroxypyridinone Derivatives: A Fascinating Class of Chelators with Therapeutic Applications - An Update

Volume: 25 Issue: 1

关键词: 羟基吡啶酮，3-羟基-4-吡啶酮，铁螯合剂，抗神经退行性药物，生物无机药物化学。

摘要: Hydroxypyridinones (HPs) are a family of N-heterocyclic metal chelators, which have been an attractive target in the development of a variety of new pharmaceutical drugs, due to their high metal chelating efficacy/specificity and easy derivatization to tune the desired biological properties. In fact, along the last decades, hydroxypyridinone derivatives, but mostly 3-hydroxy-4-pyridinone (3,4-HP), have been intensively used in drug design, following either a multitarget approach, in which one chelating unity is extrafunctionalized (hybridized) to enable the interaction with other important specific biological sites, or a polydenticity approach, in which more than one chelating moiety is conveniently attached to one scaffold, to increase the metal chelating efficacy. This review represents an update of the most recent publications (2014-2016) in mono-HP hybrids, namely as potential anti-Alzheimer's drugs, inhibitors of metalloenzymes and anti-microbials, and also polychelating compounds (poly- HP), in view of potential application, such as anti-microbial/biostatic agents, luminescent biosensors or diagnostic agents.

Cite this article as:

Hydroxypyridinone Derivatives: A Fascinating Class of Chelators with Therapeutic Applications - An Update, Current Medicinal Chemistry 2018; 25 (1) . https://dx.doi.org/10.2174/0929867324666170330092304