顺磁和超顺磁性无机纳米粒子在T1加权磁共振成像中的应用

Title:Paramagnetic and Superparamagnetic Inorganic Nanoparticles for T1-Weighted Magnetic Resonance Imaging

Volume: 25 Issue: 25

关键词: 顺磁性和超顺磁性无机纳米颗粒，钆基纳米颗粒，锰氧化物，超小氧化铁，T1加权磁共振成像，可视化理论。

摘要: Magnetic resonance imaging (MRI) has become a promising technique in the early diagnosis of cancers, especially the application of contrast agents can further enhance the detection limit. Compared with the dark signal in “negative” contrast agents (T2), “positive” contrast agents (T1) with bright signal are more desirable for high-resolution imaging. However, the clinically used gadolinium complexes have short circulation time and the risk of nephrogenic system fibrosis. Therefore, to overcome the disadvantage of T2 agents and traditional T1 agents, it is very interesting to develop nano-scaled T1-weighted MRI contrast agents with safer and more precise imaging performance. The present review systematically summarized the recent progress of paramagnetic and superparamagnetic inorganic nanoparticles as T1-weighted MRI contrast agents, including gadolinium oxide nanoparticles, gadoliniumbased upconversion nanoparticles, manganese oxide nanoparticles, and ultra-small iron oxide nanoparticles. Moreover, we also described their applications in multi-modal imaging and visualized theranostics.

Cite this article as:

Paramagnetic and Superparamagnetic Inorganic Nanoparticles for T1-Weighted Magnetic Resonance Imaging, Current Medicinal Chemistry 2018; 25 (25) . https://dx.doi.org/10.2174/0929867324666170314124616