Integration of Novel Materials and Advanced Genomic Technologies into New Vaccine Design

Title:Integration of Novel Materials and Advanced Genomic Technologies into New Vaccine Design

Volume: 17 Issue: 20

Author(s): Wenzhen Liao, Tian-Tian Zhang, Liqian Gao, Su Seong Lee, Jie Xu, Han Zhang, Zhaogang Yang, Zhaoyu Liu*Wen Li*

Affiliation:

• Center of Molecular and Translational Medicine, Georgia State University, Atlanta, GA,United States

• Department of Hematology and Medical Oncology, School of Medicine, Emory University, Atlanta, GA, 30043,United States

Keywords: Vaccine, genomics, reverse vaccinology, antigen, immune response.

Abstract: Designing new vaccines is one of the most challenging tasks for public health to prevent both infectious and chronic diseases. Even though many research scientists have spent great efforts in improving the specificity, sensitivity and safety of current available vaccines, there are still much space on how to effectively combine different biomaterials and technologies to design universal or personalized vaccines. Traditionally, vaccines were made based on empirical approaches designed to mimic immunity induced by natural infection. Either live attenuated or killed whole microorganisms were used as vaccines. With the development of biomaterial science, DNA/RNA, recombinant vector, adjuvant and nanoparticles greatly expand the category of vaccines. More importantly, with the tremendous advances of new technologies including genomics, proteomics and immunomics, the paradigm of vaccine design has shifted from microbiological to sequence-based approaches. This ever-growing large amount of genomic data and new genomic approaches such as comparative genomics, reverse vaccinology and pan-genomics, will play critical roles in novel vaccine design and enable development of more effective vaccines to cure and control both chronic and infectious diseases. In this review, we summarize current various vaccine materials, advanced technologies and combinational strategies to integrate biomaterials and advanced technologies for vaccine design, which we hope will provide some very useful guidelines and perspectives for the vaccine design.

Cite this article as:

Liao Wenzhen, Zhang Tian-Tian, Gao Liqian, Lee Seong Su, Xu Jie, Zhang Han, Yang Zhaogang, Liu Zhaoyu*, Li Wen*, Integration of Novel Materials and Advanced Genomic Technologies into New Vaccine Design, Current Topics in Medicinal Chemistry 2017; 17 (20) . https://dx.doi.org/10.2174/1568026617666170224122117