Synthesis and Anticancer Studies of Novel N-benzyl Pyridazino ne Derivatives

Title:Synthesis and Anticancer Studies of Novel N-benzyl Pyridazino ne Derivatives

Volume: 14 Issue: 9

Author(s): Mohamed Elagawany, Mohamed A. Ibrahim, Tarek S. Ibrahim, Amany M.M. AL-Mahmoudy, Alaa Moawad, Mohammed M. Ghoneim, Mohamed M. Radwan and Siva S. Panda*

Affiliation:

• Department of Chemistry & Physics, Augusta University, Augusta, GA 30912,United States

Keywords: Anticancer, pyridazinone, suzuki, buwald coupling, anti-inflammatory, cardiovascular activities.

Abstract: Introduction: According to WHO, cancer is one of the most leading causes of death. Development of anticancer drugs draw considerable attention. Pyridazinones analogues were reported to possess anticancer properties. Chemical modification of pyridazinone may lead to potential anticancer agent.

Objective: The objective of this article is to develop new pyridazinone deriatives and evaluate their anticancer activities.

Results: The target compounds were synthesized using Palladium cross coupling reactions, Buchwald and Suzuki, the synthesized compound were evaluated against BT-549, KB and SK-MEL cell lines. Some compounds showed moderate to significant inhibitory activity.

Conclusion: Novel pyridazinone derivatives were synthesized in a good yield. Some of the synthesized analogues showed good anticancer properties against BT-549, KB and SK-MEL cell lines.

Cite this article as:

Elagawany Mohamed, Ibrahim A. Mohamed, Ibrahim S. Tarek, AL-Mahmoudy M.M. Amany, Moawad Alaa, Ghoneim M. Mohammed, Radwan M. Mohamed and Panda S. Siva*, Synthesis and Anticancer Studies of Novel N-benzyl Pyridazino ne Derivatives, Letters in Drug Design & Discovery 2017; 14 (9) . https://dx.doi.org/10.2174/1570180814666170223111312

DOI https://dx.doi.org/10.2174/1570180814666170223111312	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X