Engineered Muscle Tissues for Disease Modeling and Drug Screening Applications

Title:Engineered Muscle Tissues for Disease Modeling and Drug Screening Applications

Volume: 23 Issue: 20

Author(s): Mohammad Hossein Mohammadi, Raquel Obregón, Samad Ahadian, Javier Ramón-Azcón*Milica Radisic*

Affiliation:

• Biosensors for Bioengineering group, Institute for Bioengineering of Catalonia (IBEC), Parc Científic de Barcelona (PCB), Edifici Clúster, c/ Baldiri Reixac 10-12, 08028 Barcelona,Spain

• Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9,Canada

Keywords: Cardiac muscle, Skeletal muscle, drug screening, Engineering muscle, Human pharmacological response, physiological similarity.

Abstract: Animal models have been the main resources for drug discovery and prediction of drugs’ pharmacokinetic responses in the body. However, noticeable drawbacks associated with animal models include high cost, low reproducibility, low physiological similarity to humans, and ethical problems. Engineered tissue models have recently emerged as an alternative or substitute for animal models in drug discovery and testing and disease modeling. In this review, we focus on skeletal muscle and cardiac muscle tissues by first describing their characterization and physiology. Major fabrication technologies (i.e., electrospinning, bioprinting, dielectrophoresis, textile technology, and microfluidics) to make functional muscle tissues are then described. Finally, currently used muscle tissue models in drug screening are reviewed and discussed.

Cite this article as:

Mohammadi Hossein Mohammad, Obregón Raquel, Ahadian Samad, Ramón-Azcón Javier*, Radisic Milica*, Engineered Muscle Tissues for Disease Modeling and Drug Screening Applications, Current Pharmaceutical Design 2017; 23 (20) . https://dx.doi.org/10.2174/1381612823666170215115445