The Influence of Dietary Components on Early Signs of Atherosclerosis in Apparently Healthy Young-adult Males: An Observational Study of 615 Subjects

Title:The Influence of Dietary Components on Early Signs of Atherosclerosis in Apparently Healthy Young-adult Males: An Observational Study of 615 Subjects

Volume: 15 Issue: 5

Author(s): Girolamo Catapano Minotti, Francesca Cortese*, Andrea Corsonello, Giovanni Guadalupi, Antonio Paolo D`Arcangelo, Saverio Daniele Palumbo, Rita Naio, Ottovio De Clemente, Andrea Aurelio, Simona Carone, Tiziana Gelsumino, Vincenzo Gemignani, Elisabetta Bianchini, Mariangela Vigotti, Francesco Faita, Luciano Greco, Roberto Primerano, Raffaele Antonelli Incalzi and Marco Matteo Ciccone

Affiliation:

• Cardiovascular disease Section, Department of Organ and Transplantation, University of Bari, Bari,Italy

Keywords: Diet, antioxidants, carotid intima-media thickness, flow-mediated dilation, young-adult, atherosclerosis.

Abstract: Background: The literature shows that a healthy diet, rich in fruits and vegetables, has positive effects on overall cardiovascular risk, protecting against atherosclerosis.

Design: A cross sectional study in a population of apparently healthy young-adult men with the aim of investigating dietary determinants of early atherosclerosis, assessed by measuring carotid intima-media thickness (cIMT) and flow-mediated dilation (FMD) of the brachial artery.

Methods: 615 males (mean age ± SD: 40.8±9.8 years) without overt atherosclerosis were evaluated. Dietary intake was quantified by the European Prospective Investigation into Cancer and Nutrition (EPIC) questionnaire. Intake of antioxidants was expressed in relation to total caloric intake.

Results: Neither absolute, recommended daily allowance or weight-related values of nutritional intake variables were associated with cIMT. Vitamin E to total calories intake (odds ratio, OR=0.08, 95%CI=0.03-0.89) was inversely associated with impaired FMD. Non-nutritional correlates of FMD <10% were: age (OR=1.02, 95%CI=1.0-1.05) and waist circumference (OR=1.03, 95%CI=1.0-1.06), and those of cIMT >0.8 mm were age (OR=1.10, 95%CI=1.05-1.15), pack-years (OR=1.02, 95%CI=1.0-1.04), C-reactive protein (OR=1.17, 95%CI=1.04-1.33) and total cholesterol (OR=1.01, 95%CI=1.0-1.02).

Conclusion: Differences in the factors correlating with cIMT >0.8 mm and FMD <10% might have implications for cardiovascular risk reduction. A lower antioxidant to caloric intake ratio might be a risk factor for impaired FMD.

Cite this article as:

Minotti Catapano Girolamo, Cortese Francesca*, Corsonello Andrea, Guadalupi Giovanni, D`Arcangelo Paolo Antonio, Palumbo Daniele Saverio, Naio Rita, Clemente De Ottovio, Aurelio Andrea, Carone Simona, Gelsumino Tiziana, Gemignani Vincenzo, Bianchini Elisabetta, Vigotti Mariangela, Faita Francesco, Greco Luciano, Primerano Roberto, Incalzi Antonelli Raffaele and Ciccone Matteo Marco, The Influence of Dietary Components on Early Signs of Atherosclerosis in Apparently Healthy Young-adult Males: An Observational Study of 615 Subjects, Current Vascular Pharmacology 2017; 15 (5) . https://dx.doi.org/10.2174/1570161115666170201111809

DOI https://dx.doi.org/10.2174/1570161115666170201111809	Print ISSN 1570-1611
Publisher Name Bentham Science Publisher	Online ISSN 1875-6212