Abstract
The specific recognition of any given DNA sequence by ligands is expected to revolutionize medicine and biotechnology in the future. Using oligonucleotides as sequence-specific ligands to form triple helical structures offers a particularly attractive approach due to their availability and their simple recognition code based mainly on directional hydrogen bond contacts. However, the recognition code is limited to only two out of four Watson-Crick base pairs in DNA and only homopurine sequences can be effectively targeted by triplex-forming oligonucleotides at present. In order to overcome this limitation much effort has been directed in the past to the development of novel nucleoside analogs capable of binding any given base pair. This review will summarize the different structural approaches to achieve mixed base pair recognition and try to evaluate the various contributions to binding.
Keywords: non-natural nucleosides, watson-crick base paris, triplex-forming oligonucleotides, nucleoside analogs
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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