ImmunemiR - A Database of Prioritized Immune miRNA Disease Associations and its Interactome

Title:ImmunemiR - A Database of Prioritized Immune miRNA Disease Associations and its Interactome

Volume: 6 Issue: 1

Author(s): Archana Prabahar and Jeyakumar Natarajan*

Affiliation:

• Department of Bioinformatics, Bharathiar University, Coimbatore, Tamil Nadu 641 046,India

Keywords: Autoimmune disease, immune, miRNA, miRNA-disease association, PPI interactome.

Abstract: Background: MicroRNAs are the key regulators of gene expression and their abnormal expression in the immune system may be associated with several human diseases such as inflammation, cancer and autoimmune diseases. Elucidation of miRNA disease association through the interactome will deepen the understanding of its disease mechanisms. A specialized database for immune miRNAs is highly desirable to demonstrate the immune miRNA disease associations in the interactome.

Methods: miRNAs specific to immune related diseases were retrieved from curated databases such as HMDD, miR2disease and PubMed literature based on MeSH classification of immune system diseases. The additional data such as miRNA target genes, genes coding protein-protein interaction information were compiled from related resources. Further, miRNAs were prioritized to specific immune diseases using random walk ranking algorithm.

Results: In total 245 immune miRNAs associated with 92 OMIM disease categories were identified from external databases. The resultant data were compiled as ImmunemiR, a database of prioritized immune miRNA disease associations. This database provides both text based annotation information and network visualization of its interactome.

Conclusion: To our knowledge, ImmunemiR is the first available database to provide a comprehensive repository of human immune disease associated miRNAs with network visualization options of its target genes, protein-protein interactions (PPI) and its disease associations. It is freely available at http://www.biominingbu.org/immunemir/

Cite this article as:

Prabahar Archana and Natarajan Jeyakumar*, ImmunemiR - A Database of Prioritized Immune miRNA Disease Associations and its Interactome, MicroRNA 2017; 6 (1) . https://dx.doi.org/10.2174/2211536606666170117112322

DOI https://dx.doi.org/10.2174/2211536606666170117112322	Print ISSN 2211-5366
Publisher Name Bentham Science Publisher	Online ISSN 2211-5374