维生素D对消化通路生理病理的作用和功能

Title:Action and Function of Vitamin D in Digestive Tract Physiology and Pathology

Volume: 24 Issue: 9

关键词: 消化通路生理，万花筒，胃肠道，生理学，维生素D，维生素D受体

摘要: Background: The body of biomedical literature on Vitamin D effector mechanisms in gastrointestinal biology and pathophysiology is rapidly expanding. Accordingly, new possibilities of vitamin D biology-based therapeutical intervention in gastroenterological disease are being identified. However, the literature lacks a concise review on these developments, hampering comprehension of the possibilities involved for many in the community.

Results: Genetic vitamin D receptor (VDR) polymorphisms and other VDR biology regulation are involved in predisposition to gastrointestinal cancers and might allow tailored strategies for managing those individuals especially at risk, e.g. through vitamin D supplementation. Likewise, modulation of Hedgehog signaling by vitamin D analogues may have promise in combating gastrointestinal cancers or improving barrier function in IBD, but shortage in vitamin D levels may also influence inflammatory conditions of the gut through direct interaction with the mucosal immune system. Evidence justifying population-wide monitoring for vitamin D status is accumulating.

Conclusion: There is kaleidoscopic interaction of vitamin D biology with many aspects of gastrointestinal tract biology. Vitamin D appears an attractive target for personalized approaches like precision and P4 medicine.

Cite this article as:

Action and Function of Vitamin D in Digestive Tract Physiology and Pathology, Current Medicinal Chemistry 2017; 24 (9) . https://dx.doi.org/10.2174/0929867323666161228145137

DOI https://dx.doi.org/10.2174/0929867323666161228145137	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X