Facile and Solvent-free Domino Synthesis of New Quinolidinyl-2,4- thiazolidinones: Antifungal Activity and Molecular Docking

Title:Facile and Solvent-free Domino Synthesis of New Quinolidinyl-2,4- thiazolidinones: Antifungal Activity and Molecular Docking

Volume: 18 Issue: 7

Author(s): Dnyaneshwar D. Subhedar, Mubarak H. Shaikh, Santosh G. Tupe, Mukund V. Deshpande, Vijay M. Khedkar, Prakash C. Jha and Bapurao B. Shingate*

Affiliation:

• Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, 431004,India

Keywords: Antifungal activity, ionic liquid, molecular docking, multicomponent reaction, 2, 4-thiazolidinones, solvent-free reaction.

Abstract: Objective: We have synthesized new quinolidinyl-thiazolidinones via Knoevenagel condensation- alkylation reaction, catalyzed by [Et3NH][HSO4]. The present approach offers several advantages such as higher yields, eco-friendly reaction condition and economic availability of the catalyst.

Method: The newly synthesized compounds were evaluated for their in vitro antifungal activity against six fungal strains. Some of the synthesized conjugates displayed good to moderate antifungal activity.

Conclusion: Again, the molecular docking study performed against the fungal sterol 14α-demethylase (CYP51) showed an excellent binding affinity towards the enzyme which could rationalize the promising antifungal activity portrayed by these derivatives and provides a platform for structure based drug design.

Cite this article as:

Subhedar D. Dnyaneshwar, Shaikh H. Mubarak, Tupe G. Santosh, Deshpande V. Mukund, Khedkar M. Vijay, Jha C. Prakash and Shingate B. Bapurao*, Facile and Solvent-free Domino Synthesis of New Quinolidinyl-2,4- thiazolidinones: Antifungal Activity and Molecular Docking, Mini-Reviews in Medicinal Chemistry 2018; 18 (7) . https://dx.doi.org/10.2174/1389557516666161226161152