The Role of Rho Kinase Inhibitors in Corneal Endothelial Dysfunction

Title:The Role of Rho Kinase Inhibitors in Corneal Endothelial Dysfunction

Volume: 23 Issue: 4

Author(s): Naoki Okumura, Shigeru Kinoshita and Noriko Koizumi

Affiliation:

Keywords: Cornea, Rho kinase, corneal endothelial dysfunction, fuchs endothelial corneal dystrophy.

Abstract: Background: The cornea is transparent tissue that serves as the window of the eye, allowing light to enter from the outer environment. The corneal endothelium maintains corneal transparency; thus, its dysfunction results in corneal haziness and causes severe vision loss. The only available therapeutic choice for treating corneal endothelial dysfunction has been transplantation using donor corneas; consequently, researchers have been pressed to develop new therapeutic options.

Methods: The goal of the review is to provide an overview of the research into Rho kinase (ROCK) inhibitors in the field of corneal endothelium therapy and the potential for clinical use of ROCK inhibitors.

Results: We reported that ROCK inhibitor enhances wound healing in the corneal endothelium. We further proposed the development of ROCK inhibitors as drugs that suppress the incidence of bullous keratopathy following severe corneal endothelial damage, especially that occurring during cataract surgery, one of the leading causes of corneal transplantation. We also proposed the use of ROCK inhibitors as adjunct drugs for cell-based therapeutic treatment of corneal endothelial dysfunction. ROCK inhibitors promote the engraftment of injected cultured corneal endothelial cells to the recipient cornea, thereby enabling the regeneration of corneal endothelium. Of note, we have initiated clinical research into cell injection therapy using a ROCK inhibitor as an adjunct drug.

Conclusion: This review documents the potency of ROCK inhibitors in clinical use, both as eye drops and as adjunct drugs for cell-based therapy for the treatment of corneal endothelial dysfunction.

Cite this article as:

Okumura Naoki, Kinoshita Shigeru and Koizumi Noriko, The Role of Rho Kinase Inhibitors in Corneal Endothelial Dysfunction, Current Pharmaceutical Design 2017; 23 (4) . https://dx.doi.org/10.2174/1381612822666161205110027

DOI https://dx.doi.org/10.2174/1381612822666161205110027	Print ISSN 1381-6128
Publisher Name Bentham Science Publisher	Online ISSN 1873-4286