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Current Pharmaceutical Design

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ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

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Review Article

Mesoporous Silica Molecular Sieve based Nanocarriers: Transpiring Drug Dissolution Research

Author(s): Satyanarayan Pattnaik and Kamla Pathak

Volume 23, Issue 3, 2017

Page: [467 - 480] Pages: 14

DOI: 10.2174/1381612822666161026162005

Price: $65

Abstract

Background: Improvement of oral bioavailability through enhancement of dissolution for poorly soluble drugs has been a very promising approach. Recently, mesoporous silica based molecular sieves have demonstrated excellent properties to enhance the dissolution velocity of poorly water-soluble drugs.

Description: Current research in this area is focused on investigating the factors influencing the drug release from these carriers, the kinetics of drug release and manufacturing approaches to scale-up production for commercial manufacture.

Conclusion: This comprehensive review provides an overview of different methods adopted for synthesis of mesoporous materials, influence of processing factors on properties of these materials and drug loading methods. The drug release kinetics from mesoporous silica systems, the manufacturability and stability of these formulations are reviewed. Finally, the safety and biocompatibility issues related to these silica based materials are discussed.

Keywords: Mesoporous silica, synthesis, drug loading, release, stability.

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