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Infectious Disorders - Drug Targets

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ISSN (Print): 1871-5265
ISSN (Online): 2212-3989

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Research Article

Use of Intra-Articular Amphotericin B in the Treatment of Candida parasilosis and albicans in Prosthetic Joint Infections (PJI): A Novel Approach to this Difficult Problem

Author(s): Leigh G. Cooper, Jacob Heydemann, Gregory Misenhimer and Suresh Antony

Volume 17, Issue 1, 2017

Page: [36 - 42] Pages: 7

DOI: 10.2174/1871526516666161026125606

Price: $65

Abstract

Background: Use of intra-articular antibiotics for the treatment of arthroplasty infections has gained some interest over the last few years.

Objective: Some data exists on its use with bacterial arthroplasty infections.

Method: We used intra-articular amphotericin B in an attempt to cure these joint infections and perform a one stage revision.

Results: Two patients were treated with intra-articular amphotericin B for 6 weeks followed by suppressive fluconazole for 4 months. Intra-articular joint fluid was cultured during this process for re-growth of fungus.

Conclusion: Both patients were treated successfully with the method with follow up showing no evidence of recurrence. IA administration of amphotericin B may be an alternative treatment in these patients.

Keywords: Intra-articular, amphotericin B, prosthetic joint infection, candida, treatment failure, Hickman catheter.

Graphical Abstract


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