Development of Self Emulsifying Formulations of Poorly Soluble Naproxen for Enhanced Drug Delivery

Title:Development of Self Emulsifying Formulations of Poorly Soluble Naproxen for Enhanced Drug Delivery

Volume: 10 Issue: 3

Author(s): Subhash C.B. Penjuri, Damineni Saritha, Nagaraju Ravouru and Srikanth R. Poreddy

Affiliation:

Keywords: Naproxen, SEDDS, FTIR, DSC, ICH, Cmax, Zeta potential.

Abstract: Background: The objective of this investigation was to develop a self emulsifying drug delivery system (SEDDS) of naproxen, a poorly water soluble drug, which could improve its solubility and oral bioavailability.

Methods: The recent patents on SEDDS of abiraterone acetate (WO2014/009434 A1) and tamoxifen (WO2013/0080083) helped in selecting the naproxen and excipients. Phase diagrams were constructed and the formulations were taken from the micro emulsion region. Formulations were subjected to thermodynamic stability, dispersibility and precipitation tests for optimization. Physico chemical characterization was carried out by FTIR and DSC studies. The selected SEDDS consisted of IPM+labrafac lipophile WL 1349, tween 80, PEG 400 and naproxen. The optimized formulation has globule size- 187.6 nm, zeta potential- -9.81 mv, viscosity- 1.772 cps and infinite dilution ability.

Results: In vitro drug release was 98.21% and was found to be significantly different from the marketed product and plain drug. After oral administration in rats the SEDDS of naproxen showed anti inflammatory activity (69.82%) which was much improved as compared to the marketed formulation. The Cmax, AUC0t of naproxen was boosted with SEDDS to 133.63 g/ml and 698.29 hr. g/ml respectively. The optimized formulation was found to be stable for 6 months during stability studies conducted according to the ICH Q1A (R2) guidelines.

Conclusion: Thus this developed self emulsifying drug delivery system may be a useful tool to enhance the solubility of oral poorly water soluble drug naproxen.

Cite this article as:

Penjuri C.B. Subhash, Saritha Damineni, Ravouru Nagaraju and Poreddy R. Srikanth, Development of Self Emulsifying Formulations of Poorly Soluble Naproxen for Enhanced Drug Delivery, Recent Patents on Drug Delivery & Formulation 2016; 10 (3) . https://dx.doi.org/10.2174/1872211310666161020095721

DOI https://dx.doi.org/10.2174/1872211310666161020095721	Print ISSN 1872-2113
Publisher Name Bentham Science Publisher	Online ISSN 2212-4039