Novel Indole-Isoxazole Hybrids: Synthesis and In Vitro Anti-Cholinesterase Activity

Title:Novel Indole-Isoxazole Hybrids: Synthesis and In Vitro Anti-Cholinesterase Activity

Volume: 14 Issue: 6

Author(s): Fahimeh Vafadarnejad, Mina Saeedi, Mohammad Mahdavi, Ali Rafinejad, Elahe Karimpour-Razkenari, Bilqees Sameem, Mahnaz Khanavi and Tahmineh Akbarzadeh*

Affiliation:

• Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences P.O. Box: 14155-6451, Tehran,Iran

Keywords: Acetylcholinesterase, Alzheimer’s disease, Butyrylcholinesterase, Heterocycles, Indole, Isoxazole.

Abstract: Background: This work reports synthesis and in vitro cholinesterase inhibitory activity of novel indole-isoxazole hybrids.

Method: The synthetic procedure was started from different ethyl 5-arylisoxazole-3-carboxylate derivatives. Hydrolysis and reaction of the later compound with tryptamine afforded the desired products in good yields.

Conclusion: Among the synthesized compounds, N-(2-(1H-indol-3-yl)ethyl)-5-(2-chlorophenyl) isoxazole-3-carboxamide (4b) showed the best anti-cholinesterase activity.

Cite this article as:

Vafadarnejad Fahimeh, Saeedi Mina, Mahdavi Mohammad, Rafinejad Ali, Karimpour-Razkenari Elahe, Sameem Bilqees, Khanavi Mahnaz and Akbarzadeh Tahmineh*, Novel Indole-Isoxazole Hybrids: Synthesis and In Vitro Anti-Cholinesterase Activity, Letters in Drug Design & Discovery 2017; 14 (6) . https://dx.doi.org/10.2174/1570180813666161018124726

DOI https://dx.doi.org/10.2174/1570180813666161018124726	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X