Fixed Dose Oral Dry Syrup Combination of Norfloxacin and Tinidazole Using Natural Polysaccharides: Formulation and Evaluation

Title:Fixed Dose Oral Dry Syrup Combination of Norfloxacin and Tinidazole Using Natural Polysaccharides: Formulation and Evaluation

Volume: 6 Issue: 2

Author(s): Ratna J. Das, Bitupan Bhuyan and Hemanta K. Sharma

Affiliation:

Keywords: Microspheres, natural polymer, pediatric group, pharmaceutical excipient, site of action, targeted drug delivery.

Abstract: Background: This research effort was aimed for the use of edible natural polymers from Dillenia indica and Bora rice for the preparation of palatable dry syrup containing bitter drugs Norfloxacin and Tinidazole for paediatric use.

Methods: Bora rice flour and the mucilage extracted from Dillenia indica were characterised by UV and FTIR. They were also evaluated for safety. Norfloxacin-Tinidazole loaded microspheres were prepared using the natural polymers and were evaluated. The dry syrup for pediatrics was formulated and evaluated as per protocol.

Results: The natural polymer extracted from Dillenia indica showed presence of pectin and the flour of Bora rice was found to be rich in amylopectin. Both polymers were found to be safe for use in paediatric groups. The release study performed on the microspheres exhibited the release of drugs in the intestine only and not in the stomach. The results of evaluation of the prepared dry syrup were also in conformity and the bitter taste of the drugs was masked.

Conclusion: The results of this study demonstrated that the natural polymers from Dillenia indica and Assam Bora rice can be used as pharmaceutical excipient to mask the bitter taste of drugs and to prepare formulation of targeted drug delivery.

Cite this article as:

J. Das Ratna, Bhuyan Bitupan and K. Sharma Hemanta, Fixed Dose Oral Dry Syrup Combination of Norfloxacin and Tinidazole Using Natural Polysaccharides: Formulation and Evaluation, Drug Delivery Letters 2016; 6 (2) . https://dx.doi.org/10.2174/2210303106666160926145121