Abstract
Cyclodextrins are cyclic oligosaccharides constituted by glucopyranose units linked by -(1,4) bonds that show a characteristic donut shape with a hydrophobic cavity and a hydrophilic outer surface. Cyclodextrins are capable of forming water-soluble host:guest complexes with lipophilic molecules that hide in the their cavity. The aim of the review is to describe the historical background, the structure and proprieties of natural cyclodextrins and their derivatives, their physico-chemical properties and toxicological profile. We also describe the different methods to prepare the inclusion complexes and give an overview of the various applications of such complexes in the different fields. The review discusses and summarizes the most recent literature of cyclodextrins and their application in order to give a comprehensive treatment of the main features of these tools widely used to improve the solubility and bioavailability of many compounds used in the biotechnological and pharmaceutical fields.
Keywords: Cyclodextrin, crystal structure, inclusion complex, preparation methods.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Books
Advances in Organic Synthesis
The Synthetic Methods, Structures, and Properties of the Ca-C σ Bond Organocalcium Containing Compounds
Advances in Organic Synthesis
Chemistry of Bipyrazoles: Synthesis and Applications
Advances in Organic Synthesis
Advanced Nanocatalysis for Organic Synthesis and Electroanalysis
Advances in Organic Synthesis
Advances in Organic Synthesis
41
5