Abstract
Objective: To prepare sustained release micro-/nanospheres of Ketoprofen (KFN) loaded Eudragit ® RS100 with ethyl cellulose and polycaprolactone (PCL).
Method: The sustained release micro-/nanospheres of Ketoprofen (KFN) loaded Eudragit® RS100 with ethyl cellulose and polycaprolactone (PCL) were prepared by single emulsion [oil-in-water (o/w)] solvent evaporation method. Results: The resultant micro-/nanospheres were evaluated for their size, surface morphology, encapsulation efficiency and in vitro drug release. The prepared KFN loaded Eudragit® RS100 with ethyl cellulose micro-/nanospheres was showed encapsulation efficiency in the range from 59.81% to 96.14% while KFN loaded PCL micro-/nanospheres showed 54.46% to 88.52%. The micro-/nanospheres were found discrete and globular in shape. The absence of interaction between KFN and polymers were confirmed by Fourier Transform Infrared spectroscopy (FTIR). The X-ray diffraction (XRPD) revealed the dispersion of drug within micro-/nanospheres formulation. The in-vitro drug released study showed sustained release drug profile over a period of 12 h. Conclusion: These results could be helpful for finding the optimum formulation valuables for encapsulation efficiency as well as drug released profile of sustained release micro-/nanospheres.Keywords: Ketoprofen, polymer, nanospheres, encapsulation efficiency, in-vitro drug released, ethyl cellulose and Polycaprolactone (PCL).
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