Fc Engineering to Improve the Function of Therapeutic Antibodies

Title:Fc Engineering to Improve the Function of Therapeutic Antibodies

Volume: 17 Issue: 15

Author(s): Futa Mimoto, Taichi Kuramochi, Hitoshi Katada, Tomoyuki Igawa and Kunihiro Hattori

Affiliation:

Keywords: Antibody engineering, therapeutic antibody, Fc engineering, antibody, protein engineering.

Abstract: Monoclonal antibodies are currently the most attractive therapeutic modality in a broad range of disease areas, including infectious diseases, autoimmune diseases, and oncology. Fc engineering is one attractive application to maximize the value or overcome the drawbacks of monoclonal antibodies for therapeutic use. With the Fc region, antibodies bind to several types of receptors, such as Fc gamma receptors, a complement receptor, and a neonatal Fc receptor. Through this interaction with the receptors, antibodies demonstrate unique functions, such as antibody-dependent cellular cytotoxicity, antibody- dependent cellular phagocytosis, complement dependent cytotoxicity, agonistic activity, and endosomal recycling. Fc engineering technology is conducted mainly to maximize the receptor-mediated functions of antibodies. Moreover, Fc engineering of the two heavy chains to facilitate heterodimerization is indispensable for generating IgG-like bispecific antibodies that are asymmetric. Fc engineering is also conducted to avoid the undesired properties, such as cytokine release and protease-mediated cleavage of the hinge region, of wild-type antibodies, as well as providing additional functions. Thus, Fc engineering technology is an attractive approach for maximizing the potency and convenience of therapeutic antibodies. This review will cover a variety of Fc engineering technologies that improve the functions of therapeutic antibodies.

Cite this article as:

Mimoto Futa, Kuramochi Taichi, Katada Hitoshi, Igawa Tomoyuki and Hattori Kunihiro, Fc Engineering to Improve the Function of Therapeutic Antibodies, Current Pharmaceutical Biotechnology 2016; 17 (15) . https://dx.doi.org/10.2174/1389201017666160824161854