Abstract
This review presents possible routs of preparation of acridine derivatives con-taining saturated rings that can be obtained both as a result of traditional organic synthesis based on cyclization and condensation reactions and whenever available by partial or total catalytic (heterogeneous or homogeneous) hydrogenation of appropriate acridine derivatives. Methods of preparations of acridine derivatives bearing saturated rings are presented and discussed. The influence of resonance stabilisation energies of N-heteroaromatic and partly saturated N-heteroaromatic structures on hydrogenation susceptibility is discussed in relation to other aspects influencing saturation N-heteroaromatic versus carbocyclic rings.
Keywords: Acridine, acridine derivatives, resonance stabilisation energy, condensation reactions, catalytic heterogeneous hydrogenation, catalytic homogeneous hydrogenation, selective hydrogenation.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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