The Quest for Genomic Homology

Klaas      Vandepoele; Cedric      Simillion; Yves   Van de   Peer

doi:10.2174/1389202043349237

Abstract

New initiatives to sequence complete genomes of related organisms have introduced a new era of large-scale evolutionary genomics. The comparative analysis of these genomes allows us to obtain a comprehensive view of many aspects of eukaryotic genome evolution. Consequently, new computational methods and approaches are being developed in order to investigate chromosomal organisation, rearrangements and segmental homology. Here, we review the different techniques currently available to identify homologous chromosomal segments in closely and more distantly related species and highlight some of the difficulties inherent to the statistical validation of putative genomic homology. In addition, advantages of cross-species genome analysis are discussed as well as novel approaches to study large-scale gene duplications.

Keywords: genome evolution, genomic homology, colinearity, gene duplication

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Current Genomics

Title: The Quest for Genomic Homology

Volume: 5 Issue: 4

Author(s): Klaas Vandepoele, Cedric Simillion and Yves Van de Peer

Affiliation:

Keywords: genome evolution, genomic homology, colinearity, gene duplication

Abstract: New initiatives to sequence complete genomes of related organisms have introduced a new era of large-scale evolutionary genomics. The comparative analysis of these genomes allows us to obtain a comprehensive view of many aspects of eukaryotic genome evolution. Consequently, new computational methods and approaches are being developed in order to investigate chromosomal organisation, rearrangements and segmental homology. Here, we review the different techniques currently available to identify homologous chromosomal segments in closely and more distantly related species and highlight some of the difficulties inherent to the statistical validation of putative genomic homology. In addition, advantages of cross-species genome analysis are discussed as well as novel approaches to study large-scale gene duplications.

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Cite this article as:

Vandepoele Klaas, Simillion Cedric and Peer Van de Yves, The Quest for Genomic Homology, Current Genomics 2004; 5 (4) . https://dx.doi.org/10.2174/1389202043349237

DOI https://dx.doi.org/10.2174/1389202043349237	Print ISSN 1389-2029
Publisher Name Bentham Science Publisher	Online ISSN 1875-5488

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