Pathogenesis of SLE Nephritis in the Era of Precision Medicine

Title:Pathogenesis of SLE Nephritis in the Era of Precision Medicine

Volume: 14 Issue: 2

Author(s): Renu Regunathan-Shenk*Jai Radhakrishnan*

Affiliation:

• Columbia College of Physicians & Surgeons - Medicine-Nephrology, New York, NY,United States

• Columbia College of Physicians & Surgeons - Medicine-Nephrology, New York, NY,United States

Keywords: Systemic lupus erythematosus, lupus nephritis, precision medicine, personalized medicine, genetics, ANA.

Abstract: Systemic Lupus Erythematosis (SLE) is a heterogeneous and complex disease produced by diverse pathogenic events in the innate and adaptive immune system. Lupus nephritis affects over half of all patients with lupus and leads to substantial morbidity and mortality. This review presents our current understanding of the development of lupus nephritis and examines the role of genetics and epigenetics in further elucidating the pathogenesis of the disease. Advancements in genomics are leading the way to better understanding and novel biologic therapies for SLE.

Cite this article as:

Regunathan-Shenk Renu*, Radhakrishnan Jai*, Pathogenesis of SLE Nephritis in the Era of Precision Medicine, Current Rheumatology Reviews 2018; 14 (2) . https://dx.doi.org/10.2174/1573397112666160614080121

DOI https://dx.doi.org/10.2174/1573397112666160614080121	Print ISSN 1573-3971
Publisher Name Bentham Science Publisher	Online ISSN 1875-6360