摘要
背景:在中枢神经系统(CNS)疾病中,缺血性和出血性中风等重要的医疗保健问题以及紧急入院的主要原因,主要影响神经血管结构。尽管死亡率高,发病率高,但迄今尚未建立起有效的治疗对象。目的:血液脑屏障(BBB)是临床研究和实验环境中检测到的主要影响的中风结构。 BBB由内皮,星形胶质细胞末端,周细胞和基底层组成。神经血管单位,周细胞和BBB形成的内皮在缺血性和出血性中风中起重要的病理生理作用。 讨论:在这个微型评论中,微循环和血脑屏障细胞在卒中病理生理学中的作用将以基于周细胞的特别重点为基础进行讨论。周细胞对于根据神经元组织的需要提供足够的微循环供应特别重要,并形成BBB的功能重要部分之一,并在神经血管耦合中发挥作用。了解神经血管单位元素在不同神经系统疾病中的作用和发病机制,为未来治疗提供新的靶点。
关键词: 中风,蛛网膜下腔出血,周细胞,无回流,神经血管单位。
图形摘要
Current Drug Targets
Title:The Role of Pericytes in Neurovascular Unit: Emphasis on Stroke
Volume: 18 Issue: 12
关键词: 中风,蛛网膜下腔出血,周细胞,无回流,神经血管单位。
摘要: Background: Among the central nervous system (CNS) disorders, diseases like ischemic and hemorrhagic stroke which are important health care problems as well as leading causes for emergency admissions, primarily affect neurovascular structure. Despite their high rate of mortality and morbidity, very few efficient treatment targets have been established until now. Objective: Blood-brain barrier (BBB) is the mostly effected structure in stroke as detected in both clinical studies and experimental settings. BBB is composed of endothelia, astrocyte end-foot, pericytes and basal lamina. Neurovascular unit, pericytes and BBB forming endothelia play significant pathophysiological roles in both ischemic and hemorrhagic stroke.
Discussion: In this mini-review, the role of microcirculation and cells of blood-brain barrier in stroke pathophysiology will be discussed with a special emphasis based on pericytes. Pericytes are especially important for providing adequate microcirculatory supply according to needs of neuronal tissue and form one of the functionally important part of BBB and take role in neurovascular coupling. Understanding the role and disease producing mechanisms of neurovascular unit elements in different neurological conditions will provide novel targets for future treatments.Export Options
About this article
Cite this article as:
The Role of Pericytes in Neurovascular Unit: Emphasis on Stroke, Current Drug Targets 2017; 18 (12) . https://dx.doi.org/10.2174/1389450117666160613104523
DOI https://dx.doi.org/10.2174/1389450117666160613104523 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Related Journals
Related Books
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
3D Reconstruction of a Primary Aortoenteric Fistula – Centerline Calculation and Measurements
Current Medical Imaging Should We be Concerned About the Inflammatory Response to Endovascular Procedures?
Current Vascular Pharmacology Inflammatory Biomarkers in Peripheral Artery Disease: Diagnosis, Prognosis, and Therapeutic Challenges
Current Medicinal Chemistry Therapeutic Potential of Modulating MicroRNA in Peripheral Artery Disease
Current Vascular Pharmacology Screening, Evaluation, and Early Management of Acute Aortic Dissection in the ED
Current Cardiology Reviews Review of Trans-Atlantic Cardiovascular Best Medical Therapy Guidelines – Recommendations for Asymptomatic Carotid Atherosclerosis
Current Vascular Pharmacology Application of Transcranial Color-Coded Duplex Sonography in Stroke Diagnosis
Current Medical Imaging Serum Biochemical Markers of Brain Injury
Mini-Reviews in Medicinal Chemistry Patent Selections
Recent Patents on Medical Imaging Genetic and Environmental Influences on Therapeutic and Toxicity Outcomes: Studies with CYP2A6
Current Clinical Pharmacology The Challenges of Blood Pressure Control in Dialysis Patients
Recent Advances in Cardiovascular Drug Discovery (Discontinued) Contrast-enhanced Ultrasound for Liver Imaging: Recent Advances
Current Pharmaceutical Design Coronary Intravascular Ultrasound (IVUS): Contemporary Applications and Bases for the Future
Recent Patents on Medical Imaging Screening Aortic Drug Treatments Through Arterial Compliance Measurements
Current Vascular Pharmacology Fenofibrate and Telmisartan in the Management of Abdominal Aortic Aneurysm
Current Drug Targets Recombinant Tissue-Type Plasminogen Activator (Alteplase) in the Management of Acute Ischemic Stroke: A Review of its Pharmacological Properties, Efficacy, Safety and Pharmacoeconomic Aspects
Current Drug Therapy Meet Our Section Editor
Central Nervous System Agents in Medicinal Chemistry Template-Mediated Biomineralization for Bone Tissue Engineering
Current Stem Cell Research & Therapy 9.4T Magnetic Resonance Imaging of the Mouse Circle of Willis Enables Serial Characterization of Flow-Induced Vascular Remodeling by Computational Fluid Dynamics
Current Neurovascular Research Refined Echocardiographic Assessment and Contemporary Medical Treatment of Obstructive Hypertrophic Cardiomyopathy
Cardiovascular & Hematological Disorders-Drug Targets