Abstract
Proline-amino acid chimeras are conformationally rigid amino acid analogues, important in understanding the spatial requirements for receptor affinity and biological activity of natural amino acids and peptides. In medicinal chemistry, a great variety of lysine-proline chimeras was considered in light of the importance of their biological roles. In this review, we analyze the most relevant synthetic approaches to obtain lysine-proline chimeras.
Keywords: Proline, Lysine, amino acid, synthesis, chimera, synthetic approaches.
Graphical Abstract
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