摘要
中枢神经系统(CNS)肿瘤包括脑肿瘤和脊髓。考虑到细胞类型的来源,几乎存在着120种不同类型的中枢神经系统肿瘤。良性肿瘤是不具侵袭性的,通常不侵入其他器官,但是,他们需要被手术切除,因为他们会改变周围的脑功能。原发性恶性脑肿瘤通常包括星形细胞瘤,少突胶质细胞瘤和ependimomas,其中星形细胞瘤占76%左右。世界卫生组织(WHO)已经规定了四种级别的星形细胞瘤,从低侵袭性的肿瘤(I级)到高度恶性肿瘤(IV级)。这些IV级肿瘤,又称胶质母细胞瘤(GBM),是原发性恶性脑肿瘤中最具侵袭性的。GBM患者的一般生存期为12个月至15个月。GBM目前的治疗包括手术、放疗和化疗。虽然有诊断和治疗方面的进展,但目前还没有可用于胶质母细胞瘤的最佳治疗选择。在本文中,我们将讨论对于胶质瘤的诊断及治疗方法,特别关注治疗后影像学,以及新的靶向治疗是否对GBM患者生存率有影响。此外,我们将讨论临床试验和关于胶质母细胞瘤的诊断和治疗的未来。
关键词: 胶质母细胞瘤;GBM;诊断;治疗;临床试验;放疗;替莫唑胺。
Current Molecular Medicine
Title:Diagnosis and New Treatment Modalities for Glioblastoma: Do They Improve Patient Survival?
Volume: 16 Issue: 5
Author(s): R. Alcedo-Guardia, E. Labat, D. Blas-Boria, P.E. Vivas-Mejia
Affiliation:
关键词: 胶质母细胞瘤;GBM;诊断;治疗;临床试验;放疗;替莫唑胺。
摘要: Central nervous system (CNS) malignances include tumors of the brain and spinal cord. Taking into account the cell type where they originate from, there are almost 120 different types of CNS tumors. Benign tumors are not aggressive and normally do not invade other organs; however, they require surgical removal before they alter the surrounding brain functions. Primary malignant brain tumors commonly include astrocytomas, oligodendrogliomas, and ependimomas, where astrocytomas represent around 76%. The World Health Organization (WHO) has defined four histological grades of astrocytomas that range from the less aggressive tumors (grade I) to highly malignant tumors (grade IV). These grade IV tumors, also called glioblastoma (GBM), are the most aggressive of the primary malignant brain tumors. Patients with GBM have a median survival of 12 to 15 months. Current treatment for GBM includes surgery, radiotherapy and chemotherapy. Although there have been some advances in diagnosis and treatment, there is still no optimal treatment available for GBMs. In this review, we will discuss the approaches for GBM diagnosis and treatment, with a special emphasis on post-treatment imaging, and whether novel targeted therapies have impacted the survival of GBM patients. In addition, we will discuss clinical trials and the future of GBM diagnosis and treatment.
Export Options
About this article
Cite this article as:
R. Alcedo-Guardia, E. Labat, D. Blas-Boria, P.E. Vivas-Mejia , Diagnosis and New Treatment Modalities for Glioblastoma: Do They Improve Patient Survival?, Current Molecular Medicine 2016; 16 (5) . https://dx.doi.org/10.2174/1566524016666160429120150
DOI https://dx.doi.org/10.2174/1566524016666160429120150 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Editorial:
Pharmaceutical Nanotechnology Comprehensive Quality Management (CQM) in the PLCO Trial
Reviews on Recent Clinical Trials The Role of Matrix Metalloproteinase Inhibitors in Ischemia-Reperfusion Injury in the Liver
Current Pharmaceutical Design Relevance of Micrometastases and Targeting the Bone Marrow Niche with Zoledronic Acid in Breast Cancer
Current Cancer Therapy Reviews Future Treatment for COPD: Targeting Oxidative Stress and its Related Signal
Recent Patents on Inflammation & Allergy Drug Discovery Looking Beyond Inhibition of VEGF/mTOR: Emerging Targets for Renal Cell Carcinoma Drug Development
Current Clinical Pharmacology Editorial (Thematic Issue: Genomic Applications to Various Biological Questions)
Current Genomics Correction: Targeting Leptin as a Therapeutic Strategy against Ovarian Cancer Peritoneal Metastasis
Anti-Cancer Agents in Medicinal Chemistry Anti-Inflammatory/Analgesic
Current Bioactive Compounds Protein Microarrays: Technological Aspects, Applications and Intellectual Property
Recent Patents on Biotechnology Identification and Characterization of Novel Antioxidant Peptides Involved in Redox Homeostasis of Frog, Limnonectes fragilis
Protein & Peptide Letters Mechanism of Oxidative Broncho-Epithelial Cell Damage with Reference to Gas Phase Cigarette Smoke
Mini-Reviews in Organic Chemistry Unravelling the Genetic Susceptibility to Develop Ligament and Tendon Injuries
Current Stem Cell Research & Therapy Epigenetic alterations as a universal feature of cancer hallmarks and a promising target for personalized treatments
Current Topics in Medicinal Chemistry Emerging Insight into MAPK Inhibitors and Immunotherapy in Colorectal Cancer
Current Medicinal Chemistry A Facile “Click Chemistry” Approach to Novel Flavonol Glycoconjugates and Their Cytotoxic Activity
Letters in Organic Chemistry Editorial from Guest Editor. Chronic Cough
Current Respiratory Medicine Reviews Exploring QSAR of Flavonoids as Scavengers of Peroxynitrite Using Electrotopological State (E-State) Atom Parameter
Letters in Drug Design & Discovery Recent Progress in Signal Transduction Research of the Angiotensin II Type-1 Receptor: Protein Kinases, Vascular Dysfunction and Structural Requirement
Current Medicinal Chemistry - Cardiovascular & Hematological Agents Anti-Angiogenic Approaches to Malignant Gliomas
Current Cancer Drug Targets