The Chemistry of Galanthamine. Classical Synthetic Methods and Comprehensive Study on its Analogues

Title:The Chemistry of Galanthamine. Classical Synthetic Methods and Comprehensive Study on its Analogues

Volume: 16 Issue: 18

Author(s): Péter Keglevich, Csaba Szántay and László Hazai

Affiliation:

Keywords: Acetylcholinesterase inhibition, Alzheimer's disease, butyrylcholinesterase inhibitor, galanthamine, hexahydrobenzofurobenzazepine, structural analogues.

Abstract: Galanthamine as an Amaryllidaceae alkaloid has an important role in the treatment of Alzheimer’s disease. Some efforts were made to elaborate the total synthesis, and hundreds of its derivatives were prepared to find a more effective molecule with advantageous properties. Moreover, almost every part of the tetracycle was changed; in members of the rings, in the nature and position of the heteroatoms, and ring-opened analogues were also synthesized. In this review the basic synthetic works and the most important derivatives and analogues are overviewed.

Cite this article as:

Keglevich Péter, Szántay Csaba and Hazai László, The Chemistry of Galanthamine. Classical Synthetic Methods and Comprehensive Study on its Analogues, Mini-Reviews in Medicinal Chemistry 2016; 16 (18) . https://dx.doi.org/10.2174/1389557516666160321114556