摘要
肿瘤生长和发展的机制与激活不同过程如新生血管和血管再生有关。这些过程与肿瘤和基质细胞有关。因此,抑制血管再生影响不同类型患者的肿瘤生长和增殖。尽管如此,肿瘤细胞和基质细胞在抵制抗血管增生治疗担任主要角色。大多数肿瘤对这种治疗有响应,而一些肿瘤没有响应(内在抗性),并且其他肿瘤在治疗过程表达出抵抗作用(获得性抵抗)。为预防抵抗已经提出了不同的方案,为了防止或者推迟肿瘤抵抗抗血管再生治疗,前临床研究和临床试验正在调整这种治疗方法。
关键词: 获得性抵抗;抗血管再生治疗;内在抗性;基质细胞;肿瘤细胞
图形摘要
Current Drug Targets
Title:Antiangiogenic Resistance: Novel Angiogenesis Axes Uncovered by Antiangiogenic Therapies Research
Volume: 17 Issue: 15
Author(s): Gabriela Jiménez-Valerio, Oriol Casanovas
Affiliation:
关键词: 获得性抵抗;抗血管再生治疗;内在抗性;基质细胞;肿瘤细胞
摘要: The mechanisms of tumor growth and progression involve the activation of different processes such as neovascularization and angiogenesis. These processes involve tumoral cells and stromal cells. Hence, inhibiting angiogenesis affects tumor growth and proliferation in patients with different types of cancer. Nevertheless, tumoral cells and stromal components are responsible for the resistance to antiangiogenic therapies. The majority of tumors respond to this type of therapy; however, some tumors may be indifferent to antiangiogenic therapies (intrinsic resistance) and other tumors become resistant during treatment (acquired resistance). Different strategies have been proposed to prevent resistance. Preclinical studies and clinical trials are focused to fight this therapeutic approach in order to prevent or delay tumor resistance to antiangiogenic therapies.
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Cite this article as:
Gabriela Jiménez-Valerio, Oriol Casanovas , Antiangiogenic Resistance: Novel Angiogenesis Axes Uncovered by Antiangiogenic Therapies Research, Current Drug Targets 2016; 17 (15) . https://dx.doi.org/10.2174/1389450117666160301101425
DOI https://dx.doi.org/10.2174/1389450117666160301101425 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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