Imidazole Derivatives as Potential Therapeutic Agents

Title:Imidazole Derivatives as Potential Therapeutic Agents

Volume: 22 Issue: 21

Author(s): Archana Sharma, Vipin Kumar, Rajeev Kharb, Sunil Kumar, Prabodh Chander Sharma and Dharam Pal Pathak

Affiliation:

Keywords: Imidazoles, synthesis, click chemistry, antimicrobial, anticancer.

Abstract: Background: The imidazole nucleus is inimitable and ubiquitous and it is very well known to play an important role in living organisms. Imidazole derivatives are under intensive scientific exploration due to their diverse and significant pharmacological activities. Methods: The present paper is an attempt to discuss chemistry, synthetic aspects including click chemistry procedures of imidazoles through systematic literature survey. Results: Biological activity profiles of the imidazole derivatives reported in recent scientific literature from 2000 to 2015 have been discussed in detail. It has been found that imidazole derivatives depict appreciable antiinfective activity potential. Conclusion: It is anticipated that the information compiled in this paper will be useful and motivating to prospective researchers working on this heterocylic scaffold.

Cite this article as:

Sharma Archana, Kumar Vipin, Kharb Rajeev, Kumar Sunil, Sharma Chander Prabodh and Pathak Pal Dharam, Imidazole Derivatives as Potential Therapeutic Agents, Current Pharmaceutical Design 2016; 22 (21) . https://dx.doi.org/10.2174/1381612822666160226144333