摘要
背景:过去几年,生物医学领域基于氧化铁的纳米颗粒的生产和应用由于其特殊性质而引起了极大兴趣。由于制药业的扩张,出现了许多用于药物递送的新系统,以磁性纳米颗粒为中心的系统受到特别关注并处于不同的有前途的发展阶段。 目的:在这个小型综述中,介绍了近期(过去5 - 6年)获得的一些有代表性,有趣和可行的磁性纳米结构,可能用于抗肿瘤/抗癌治疗。 结果:具有磁性的这些纳米结构的合成意味着非常简单的组装程序并且呈现最低的细胞毒素谱之一。磁性纳米结构在生物技术和医学领域显示出可能的用途,用于诊断和治疗。 结论:考虑了不同类型的载有不同抗肿瘤/抗癌剂的磁性纳米载体以及体内测试的病例。
关键词: 功能化的磁性纳米结构,抗癌疗法,药物递送,联合药物释放,成像和高温
图形摘要
Current Drug Targets
Title:Functionalized Magnetic Nanostructures for Anticancer Therapy
Volume: 19 Issue: 3
关键词: 功能化的磁性纳米结构,抗癌疗法,药物递送,联合药物释放,成像和高温
摘要: Background: In the last years, the production and applications of nanoparticles based on iron oxides in the field of biomedicine presented a great interest due to their particular properties. Because of the expansion of the pharmaceutical industry numerous new systems for drugs delivery have appeared, and those centered on magnetic nanoparticles are in a particular attention and in different promising developmental stages.
Objective: In this mini review, some representative, interesting and feasible magnetic nanostructures obtained recently (from last 5-6 years) with possible use in antitumor/anticancer therapy are presented.
Results: The synthesis of these nanostructures with magnetic properties implies very simple assembling procedures and presents one of the lowest cytotoxic profiles. Magnetic nanostructures displayed possible appliance in a large diversity of biotechnological and medical fields, both for diagnose and therapy.
Conclusion: Different types of magnetic nano-carriers loaded with different antitumor/anticancer agents and the cases tested in vivo are considered.
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Cite this article as:
Functionalized Magnetic Nanostructures for Anticancer Therapy, Current Drug Targets 2018; 19 (3) . https://dx.doi.org/10.2174/1389450117666160208145835
DOI https://dx.doi.org/10.2174/1389450117666160208145835 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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